A comparative genomic analysis of Xanthomonas arboricola pv. juglandis strains reveal hallmarks of mobile genetic elements in the adaptation and accelerated evolution of virulence.

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dc.contributor.authorAssis, Renata de Almeida Barbosa
dc.contributor.authorVarani, Alessandro de Mello
dc.contributor.authorSagawa, Cintia Helena Duarte
dc.contributor.authorPatané, José Salvatore Leister
dc.contributor.authorSetubal, João Carlos
dc.contributor.authorUceda-Campos, Guillermo
dc.contributor.authorSilva, Aline Maria da
dc.contributor.authorZaini, Paulo Adriano
dc.contributor.authorAlmeida Junior, Nalvo Franco de
dc.contributor.authorMoreira, Leandro Marcio
dc.contributor.authorDandekar, Abhaya M.
dc.date.accessioned2023-05-03T19:32:23Z
dc.date.available2023-05-03T19:32:23Z
dc.date.issued2021pt_BR
dc.description.abstractXanthomonas arboricola pv. juglandis (Xaj) is the most significant aboveground walnut bacterial pathogen. Disease management uses copper-based pesticides which induce pathogen resistance. We examined the genetic reper- toire associated with adaptation and virulence evolution in Xaj. Comparative genomics of 32 Xaj strains reveal the possible acquisition and propagation of virulence factors via insertion sequences (IS). Fine-scale annotation revealed a Tn3 transposon (TnXaj417) encoding copper resistance genes acquired by horizontal gene transfer and associated with adaptation and tolerance to metal-based pesticides commonly used to manage pathogens in orchard ecosystems. Phylogenomic analysis reveals IS involvement in acquisition and diversification of type III effector proteins ranging from two to eight in non-pathogenic strains, 16 to 20 in pathogenic strains, besides six other putative effectors with a reduced identity degree found mostly among pathogenic strains. Yersiniabactin, xopK, xopAI, and antibiotic resistance genes are also located near ISs or inside genomic islands and structures resembling composite transposons.pt_BR
dc.identifier.citationASSIS, R. de A. B. et al. A comparative genomic analysis of Xanthomonas arboricola pv. juglandis strains reveal hallmarks of mobile genetic elements in the adaptation and accelerated evolution of virulence. Genomics, v. 113, p. 2513-2525, 2021. Disponível em: <https://www.sciencedirect.com/science/article/pii/S0888754321002196>. Acesso em: 11 out. 2022.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.ygeno.2021.06.003pt_BR
dc.identifier.issn0888-7543
dc.identifier.urihttp://www.repositorio.ufop.br/jspui/handle/123456789/16508
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseThis is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Fonte: o PDF do artigo.pt_BR
dc.subjectCopper resistancept_BR
dc.subjectGenome evolutionpt_BR
dc.subjectReplicative transpositionpt_BR
dc.subjectLateral gene transferpt_BR
dc.subjectMobile genetic elementspt_BR
dc.titleA comparative genomic analysis of Xanthomonas arboricola pv. juglandis strains reveal hallmarks of mobile genetic elements in the adaptation and accelerated evolution of virulence.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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