Enhanced schistosomicidal efficacy of tartar emetic encapsulated in pegylated liposomes.

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dc.contributor.authorMelo, Alan Lane de
dc.contributor.authorBarcellos, Neila Marcia Silva
dc.contributor.authorDemicheli, Cynthia Peres
dc.contributor.authorFrezard, Frederic Jean Georges
dc.date.accessioned2014-09-29T23:56:23Z
dc.date.available2014-09-29T23:56:23Z
dc.date.issued2003
dc.description.abstractThe aim of the present study was to evaluate the ability of liposomes to improve the efficacy of tartar emetic (TA) against established Schistosoma mansoni infection. TA was used as a schistosomicidal drug model and both conventional liposomes (CL) and long-circulating pegylated liposomes (LCL) were evaluated. In the first experiment, TA, either free or encapsulated within CL or LCL, was given intraperitoneally (i.p.) as a single dose of 11 mg Sb/kg to mice experimentally infected with S. mansoni. Only the group treated with LCL showed a significant (55%) reduction in the worm burden, compared to the control groups (untreated or treated with empty LCL). In the second experiment, the efficacy of TA-containing LCL was evaluated at a higher dose (27 mg Sb/kg) by both subcutaneous (s.c.) and i.p. routes. Reduction levels of 67 and 82% were achieved by s.c. and i.p. routes, respectively. Strikingly, all mice survived to this high dose of antimony. This is in contrast with free TA that was lethal in 100% of mice at the same dose. The present work demonstrates that LCL reduce the acute toxicity of TA and effectively deliver this drug to S. mansoni during the late stages of parasite infection.pt_BR
dc.identifier.citationMELO, A. L. et al. Enhanced schistosomicidal efficacy of tartar emetic encapsulated in pegylated liposomes. International Journal of Pharmaceutics, v. 255, p. 227-230, 2003. Disponível em: <http://www.sciencedirect.com/science/article/pii/S037851730300125X>. Acesso em: 20 ago. 2014.pt_BR
dc.identifier.doihttp://dx.doi.org/10.1590/S0100-40422012000600031
dc.identifier.issn0378-5173
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/3640
dc.language.isoen_USpt_BR
dc.rights.licenseO periódico International Journal of Pharmaceutics concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 3456621140408.pt_BR
dc.subjectLiposomespt_BR
dc.subjectTartar emeticpt_BR
dc.subjectSchistosomiasispt_BR
dc.subjectAntimonypt_BR
dc.subjectSchistosoma mansonipt_BR
dc.titleEnhanced schistosomicidal efficacy of tartar emetic encapsulated in pegylated liposomes.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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