Browsing by Author "Moura, Samara Silva de"

Now showing 1 - 10 of 10
  • No Thumbnail Available
    Item
    Acute volume expansion decreased baroreflex response after swimming but not after running exercise training in hypertensive rats.
    (2019) Fernandes, Élida Mercês Raimundo; Moura, Samara Silva de; Silva, Ronan Oliveira; Totou, Nádia Lúcia; Baleeiro, Raianne dos Santos; Oliveira, Emerson Cruz de; Coelho, Daniel Barbosa; Cardoso, Leonardo Máximo; Oliveira, Lenice Kappes Becker
    Background: Physical training (ET) is important to restore the reflex sensitivity involved in controlling blood pressure in various diseases. Recent investigations have demonstrated an interaction between cardiopulmonar baroreceptors and arterial baroreflex during dynamic exercise.Objective: Considering that acute and chronic hemodynamic responses to swimming (SW) are different from the race (RUN), the objective of this study was to evaluate the effect of SW and RUN on baroreflex response before and after acute volume expansion in spontaneously hypertensive rats (SHR).Methods: SHR were divided into three groups: RUN, SW and sedentary (SED) groups. After training, the mean arterial pressure (MAP) and heart rate (HR) were recorded. Baroreflex response was assessed before and after acute volume expansion.Results: Both ET conditions reduced basal levels of HR and MAP. The first volume of injected isotonic saline solution (1.25% of body weight) produced a greater decrease in HR for the SW group (−105.8 ± 8.7 bpm) compared to RUN groups (−68 ± 5.2 bpm) and SED(−49.8 ± 7.2 bpm). Both training modalities increase the baroreflex response in relation to the SED group, but after the total volume expansion, the SW group presented attenuated response (0.7 ± 0.1 μPIms/mmHg) compared to RUN (1.5 ± 0.17 PIms/mmHg) and was not different from SED group (0.8 ± 0.2 mPIms/mmHg). Conclusion: The results show that the swim-trained group has a different baroreflex response to that observed by the run-trained group after the activation of the load receptors by saline expansion.
  • No Thumbnail Available
    Item
    Angiotensin-(1–7) oral formulation improves physical performance in mountain bike athletes : a double‐blinded crossover study.
    (2021) Moura, Samara Silva de; Mendes, Adália Táci Pereira; Martins Junior, Francisco de Assis Dias; Totou, Nádia Lúcia; Coelho, Daniel Barbosa; Oliveira, Emerson Cruz de; Santos, Daisy Motta; Santos, Robson Augusto Souza dos; Oliveira, Lenice Kappes Becker
    Background: The ECA2/Ang-(1–7)/Mas axis is shown to be involved in effects mediated by physical exercise, as it can induce the release of nitric oxide (ON) and bradykinin (BK), which are potent vasodilators. The vasodilating action the NO/BK can contribute to increased metabolic efficiency in muscle tissue and central nervous system. The formulation HPβ-CD-Ang-(1–7) through its mechanisms of action can be a promising supplement to aid in the maintenance and improvement of performance and may also favor recovery during competitions. The premise of this study was to investigate the effects of acute oral supplementation HPβ-CD-Ang-(1–7) on the performance of mountain bike (MTB) practitioners. Methods: Fourteen recreational athletes, involved in training programs for at least one year, participated in this crossover design study. Subjects underwent two days of testing with a seven-day interval. HPβ-CD-Ang-(1–7) (1.75 mg) and HPβCD-Placebo were provided in capsules three hours prior to tests. To determine the safety of the HPβ-CD-Ang-(1–7) formulation associated with physical effort, cardiovascular parameters heart rate (HR) and blood pressure (BP) were analyzed. Physical performance was measured using maximal oxygen uptake (VO2), total exercise time (TET), mechanical work (MW), mechanical efficiency (ME), and rating of perceived exertion (RPE). Respiratory exchange coefficient (REC), lactate and non-esterified fatty acids (NEFAs) were measured. Maximal incremental tests were performed on a progressively loaded leg cycle ergometer. Results: There were no significant differences in terms of HR or BP at rest and maximum effort between the HPβ-CD-Ang- (1–7) and placebo groups. The VO2max showed significant differences (p = 0.04). It was higher in the Ang-(1–7)condition (66.15 mlO2.kg− 1 .min− 1 ) compared to the placebo (60.72 mlO2.kg− 1 .min− 1 ). This was also observed for TET (Ang-(1–7) 39.10 min vs. placebo 38.14 min; p = 0.04), MW (Ang-(1–7) 156.7 vs. placebo 148.2; p = 0.04), and at the lowest RPE (Ang-(1–7) vs. placebo; p = 0.009). No significant differences were observed for REC, NEFAs, or Lactate. Conclusions: These results suggest that HPβ-CD-Ang-(1–7) improves the physical performance of MTB recreational athletes and could be a promising supplement. Trial registration: RBR-2 × 56pw8, registered January 15th, 2021. The study was prospectively registered.
  • No Thumbnail Available
    Item
    Coordenação motora de escolares do Ensino Fundamental : influência de um programa de intervenção.
    (2017) Fernandes, Swand de Paula; Moura, Samara Silva de; Silva, Siomara Aparecida da
    O desenvolvimento da criança é um processo contínuo, dinâmico e não linear, no qual o movimento configura uma das necessidades vitais do ser humano. Este estudo quase-experimental teve por objetivo analisar a magnitude da mudança no nível coordenativo de 43 escolares com idade entre 6 e 7 anos, de ambos os sexos, submetidos a dois distintos programas de intervenção de atividades físicas, separados em grupo experimental (GE) e grupo controle (GC). Para avaliar a coordenação motora utilizou-se o Körperkoordinationstest Test Für Kinder (KTK). Os dados foram submetidos à análise estatística aplicando-se os testes de normalidade e t – student (para amostras independentes e para amostras pareadas). Os resultados indicaram que, no geral, os meninos obtiveram escores médios superiores aos das meninas, e, houve um decréscimo nos níveis de coordenação em escolares com idade mais avançada. Além disso, constatou-se que o GE obteve índices mais elevados que o GC.
  • No Thumbnail Available
    Item
    Eccentric overload muscle damage is attenuated by a novel angiotensin- (1-7) treatment.
    (2018) Oliveira, Lenice Kappes Becker; Totou, Nádia Lúcia; Moura, Samara Silva de; Kangussu, Lucas Miranda; Sinisterra Millán, Ruben Dario; Santos, Maria Jose Campagnole dos; Coelho, Daniel Barbosa; Santos, Daisy Motta; Santos, Robson Augusto Souza dos
    The development of new strategies to attenuate exercise-induced muscle damage may be helpful for training regimens. The aim of this study was to determine whether a oral formulation of angiotensin Ang-(1-7)[HPβCD/Ang-(1-7)] is effective to reduce pain, and muscle damage markers after eccentric-overload exercise. HPβCD (Placebo) and HPβCD/Ang-(1-7) (Ang-(1-7) group were treated for 7 days (one capsule/day). The pain was measured by visual analogue scale, maximal strength (MS) using force platform. Blood samples were collected for cytokines and creatine kinase (CK) analysis. The Ang-(1-7)-treated group reported less pain immediately (3.46± 0.64 vs. placebo 3.80± 0.77 cm) and 24h after exercise (3.07±0.71 vs. 3.73±0.58cm placebo) and higher MS at 24h (24±12N) and 48h (30±15N) vs. placebo (-8 ± 9 N and -10 ± 9 N). The CK for Ang-(1-7) (0.5 ± 0.1 and 0.9±0.2 U/L) were lower at 48 and 72h vs. placebo (fold changes of 1.7±0.5 and 1.5±0.3 U/L). The TNF-α level was lower in the treated group post-exercise (38 ± 2.5 pg/ml) vs. placebo (45 ± 2.9 pg/ml) but no significant changes were observed for IL-6 and IL-10. Our data indicate that treatment with Ang-(1-7) may attenuate pain, some of the muscle damage markers and improves performance following eccentric exercise.
  • No Thumbnail Available
    Item
    Efeito da formulação oral HPβCD-Angiotensina-(1-7) na lesão muscular e rendimento físico de atletas de mountain bike : um estudo crossover duplo-cego.
    (2020) Moura, Samara Silva de; Oliveira, Lenice Kappes Becker; Santos, Daisy Motta; Oliveira, Lenice Kappes Becker; Santos, Daisy Motta; Gonçalves, Reginal; Silva, Fernanda Guimarães Drummond e
    Constantemente, pesquisas buscam associação de novos suplementos no rendimento esportivo. Estudos prévios em animais e humanos sugerem que a formulação oral HPβCD-Angiotensina-(1-7) poderia aumentar o rendimento físico, visto que induz a liberação de óxido nítrico e potencializa a ação da bradicinina. Além disso, a Ang-(1-7) pode estar envolvida na utilização de ácidos graxos não esterificados liberados dos adipócitos, o que possivelmente pode contribuir para maior β-oxidação, poupando a glicose hepática e muscular, contribuindo, dessa forma, para uma menor variação de glicose plasmática, sugerindo uma melhoria global na eficiência metabólica. A premissa deste estudo foi investigar o efeito da suplementação oral HPβCD-Angiotensina-(1-7) no rendimento esportivo de atletas de mountain bike (MTB). Participaram do estudo 10 atletas de MTB da região de Ouro Preto/MG, envolvidos em seus programas de treinamento por pelo menos um ano. Os ensaios experimentais foram delineados de maneira cruzada, dupla-cega, randomizada, separados por 7 dias. A administração oral de HPβCD-Ang-(1-7) (2mg) e HPβCD-Placebo em cápsulas, 3 horas antes dos testes. Para investigar os efeitos da formulação HPβCD-Ang-(1-7) em parâmetros cardiovasculares, foram avaliadas a frequência cardíaca e a pressão arterial em repouso e no pico de esforço máximo. O rendimento físico foi avaliado por meio de um teste de contrarrelógio (TT20km) em um cicloergomêtrico de pernas. Medidas perceptivas foram consideradas: percepção subjetiva de esforço (PSE) foi registrada a cada 2 km, durante os 20km e, percepção subjetiva de esforço da sessão de teste (sPSE). Amostras de sangue foram colhidas pré, pós, 24 e 48h após os testes físicos, para avaliar os parâmetros bioquímicos: lactato, ácidos graxos não esterificados (AGNEs), glicemia e creatina quinase (CK). Os dados foram expressos em média ± desvio padrão da média e o nível de significância adotado foi de p < 0,05. Não foram observadas diferenças significativas para as variáveis de rendimento físico, medidas de percepção do esforço físico: PSE e PSE da sessão e variáveis bioquímicas (AGNEs, lactato, glicose e CK). Para as variáveis cardiovasculares, os resultados exibem uma diferença significativa na PAM (p=0,004) e PAD (p=0,02) de repouso, o mesmo não foi observado para PAS e FC de repouso e máxima. A suplementação com Ang-(1-7) não melhorou o desempenho físico de atletas de MTB em um protocolo de contrarrelógio.
  • No Thumbnail Available
    Item
    Exercise reduced plasmatic oxidative stress and protected the muscle of malnourished-recovering trained rats.
    (2020) Oliveira, Emerson Cruz de; Moura, Samara Silva de; Silva, Albená Nunes da; Silva, Maísa; Gonçalves, Allan Cristian; Oliveira, Lenice Kappes Becker; Coelho, Daniel Barbosa; Pedrosa, Maria Lúcia; Silva, Marcelo Eustáquio
    The purpose of this study was to evaluate the effects of aerobic exercise training on the redox status of the heart, skeletal muscle, and the liver in previously malnourished rats. There were 3 Groups: (a) Control Group (n = 8, never malnourished); (b) Recovering Group (n = 8, malnourished for 28 days); and (c) Recovering Trained Group (n = 8, malnourished for 28 days and then exercised for 9 wks). The recovery period was not enough to restore body weight and exercise decreased body weight even further. Exercise reduced sulfhydryl levels and did not affect other blood metabolic parameters. Exercise also increased the catalase activity in skeletal muscle and carbonyl protein levels in the heart. Exercise decreased the TBARS level in the liver and heart. The recovery period was not enough to restore body weight after malnourishment. Exercise reduced plasmatic oxidative stress and protected the muscle from oxidative stress by elevating the catalase levels.
  • No Thumbnail Available
    Item
    Respostas cardiorrespiratórias induzidas pela educação física escolar.
    (2018) Moura, Samara Silva de; Santos, Tássia Mara Silva dos; Aguiar, Giovana; Coelho, Daniel Barbosa; Oliveira, Lenice Kappes Becker
    Introdução: A promoção do estilo de vida ativo na escola se fundamenta pelo fato de que é o local onde as crianças ou adolescentes experimentam a prática do exercício físico sem restrições de formação, sexo e raça. Objetivo: O presente estudo objetivou avaliar o impacto das aulas de Educação Física Escolar (EFE) em 23 escolares. As variáveis avaliadas foram: consumo máximo de oxigênio (O2max), pressão arterial (PA), frequência cardíaca (FC) e capacidade pulmonar, nos momentos pré, durante e logo após as aulas de EFE (aula de peteca e futebol). Resultados: Os valores de O2max não foram diferentes em ambos os sexos. Para a FC, em ambos os sexos houve aumento no momento pós em comparação com o pré e durante as aulas EFE. Na variável PA sistólica (PAS) houve um aumento significativo (p=0,02) para os meninos após as aulas (134±4,3 mmHg), em comparação com o pré (120±4,3 mmHg), já para a PA diastólica (PAD) não foram observadas diferenças (p=0,70). No sexo feminino não foram encontradas alterações significativas em PAS (p=0,07) e PAD (p=0,66). Em relação à função pulmonar não foram encontradas diferenças significativas em ambos os sexos para valores absolutos, porém o delta da capacidade vital forçada (CVF) foi significativamente maior (p= 0,02) para os meninos (0,95 ± 1,52 L) em comparação com as meninas (-0,28 ± 0,95 L). Conclusão: Sendo assim, o presente estudo conclui que as duas aulas de EFE observadas produziram pouco impacto na função cardiovascular e pulmonar dos estudantes embora para os meninos tenham sido percebidas maiores alterações nos parâmetros avaliados.
  • No Thumbnail Available
    Item
    Swimming exercise demonstrates advantages over running exercise in reducing proteinuria and glomerulosclerosis in spontaneously hypertensive rats.
    (2018) Totou, Nádia Lúcia; Moura, Samara Silva de; Coelho, Daniel Barbosa; Oliveira, Emerson Cruz de; Oliveira, Lenice Kappes Becker; Lima, Wanderson Geraldo de
    Experimental studies in animal models have described the benefits of physical exercise (PE) to kidney diseases associated with hypertension. Land- and water-based exercises induce different responses in renal function. Our aim was to evaluate the renal alterations induced by different environments of PE in spontaneously hypertensive rats (SHRs). The SHRs were divided into sedentary (S), swimming exercise (SE), and running exercise (RE) groups, and were trained for 8 weeks under similar intensities (60 min/day). Arterial pressure (AP) and heart rate (HR) were recorded. The renal function was evaluated through urinary volume at each week of training; sodium and potassium excretions, plasma and urinary osmolarities, glomerular filtration rate (GFR), levels of proteinuria, and renal damage were determined. SE and RE rats presented reduced mean AP, systolic blood pressure, and HR in comparison with S group. SE and RE rats showed higher urine osmolarity compared with S. SE rats showed higher free water clearance (P < 0.01), lower urinary density (P < 0.0001), and increased weekly urine volume (P < 0.05) in comparison with RE and S groups. GFR was increased in both SE and RE rats. The proteinuria of SE (7.0 ± 0.8 mg/24 h) rats was decreased at the 8th week of the PE in comparison with RE (9.6 ± 0.8 mg/24 h) and S (9.8 ± 0.5 mg/24 h) groups. The glomerulosclerosis was reduced in SE rats (P < 0.02). SE produced different response in renal function in comparison with RE, in which only swimming-trained rats had better profile for proteinuria and glomerulosclerosis.
  • No Thumbnail Available
    Item
    The curcumin supplementation with piperine can influence the acute elevation of exercise-induced cytokines : double-blind crossover study.
    (2022) Castro, Stéfani Miranda; Martins, Felipe José Aidar; Moura, Samara Silva de; Barbosa, Lucas Soares Marcucci; Lobo, Lázaro Fernandes; Martins Junior, Francisco de Assis Dias; Silva Filha, Roberta da; Castro, Pedro Alves Soares Vaz de; Silva, Ana Cristina Simões e; Souza, Danielle da Glória de; Silva, Siomara Aparecida da; Pinto, Kelerson Mauro de Castro; Costa, Guilherme de Paula; Silva, Ana Filipa; Clemente, Filipe Manuel; Pereira, William Valadares Campos; Silva, Albená Nunes da
    Background: to evaluate the effects of one week of supplementation with curcumin combined with piperine on physical performance, immune system cell counts, muscle damage, and plasma levels of inflammatory markers after a treadmill running training session. Methods: This study is a double-blind, crossover-balanced clinical trial with a three-week intervention. Sixteen male runners with a mean age of 36 ± 9 years and VO2 max of 60.6 ± 9.03 mL.kg −1 min −1 were recruited and randomly divided into 2 groups: the first group (CPG) was supplemented daily for 7 days with 500 mg of curcumin + 20 mg piperine, and the second group (PG) was supplemented with 540 mg of cellulose. After the 7th day of supplementation, the volunteers participated in the experimental running protocol, where blood samples were collected before, after, and one hour after exercise for analysis of the number of leukocytes, creatine kinase, and cytokine concentration (IL-2, TNF-α, IFN, IL-6, and IL-10) using flow cytometry. This process was repeated, reversing the supplementation offered to the groups. Results: curcumin and piperine supplementation could not change the physical performance, immune cell counts, and muscle damage; however, the aerobic fatiguing exercise protocol inhibited the elevation of the plasmatic levels of some cytokines. The running exercise protocol could elevate the circulating levels of IL-2 (from 49.7 to 59.3 pg/mL), TNF-α (from 48.5 to 51.5 pg/mL), INF (from 128.8 to 165.0 pg/mL), IL-6 (from 63.1 to 77.3 pg/mL), and IL-10 (from 48.9 to 59.6 pg/mL) 1 h after the end of the running protocol. However, the curcumin and piperine supplementation could inhibit this elevation. Conclusions: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation
  • No Thumbnail Available
    Item
    Use of diuretics is associated with higher risk of sarcopenia in older adults with hypertension.
    (2022) Martins Junior, Francisco de Assis Dias; Mateo, Dahany Pamela Acta; Silva, Fábio Junior de Miranda; Moura, Samara Silva de; Oliveira, Emerson Cruz; Coelho, Daniel Barbosa; Bearzoti, Eduardo; Pinto, Kelerson Mauro de Castro; Oliveira, Lenice Kappes Becker
    Background: Sarcopenia is a disease that involves skeletal muscle mass loss and is highly prevalent in the older adult population. Moreover, the incidence of sarcopenia is increased in patients with hypertension. Objective: The study aimed to evaluate the association between the classes of the drugs used for arterial hypertension treatment and the presence or absence of sarcopenia. Methods: 129 older adults with hypertension were evaluated by the researchers who registered the participants medication for arterial hypertension treatment. Sarcopenia level was measured by anthropometric parameters, muscular strength, and functional capacity. The data were analyzed by one-way ANOVA followed by post-hoc test and Fisher’s exact test; statistical significance was set at 0.05. Results: Age was not different between women with different levels of sarcopenia, but significant differences were observed between men with absent sarcopenia (66.8±4.2 years) and men with probable sarcopenia (77.0±10.2 years). Individuals with absent sarcopenia showed higher handgrip strength (men: 33.8±7.4, women: 23.2±4.6 Kgf) in comparison with those with sarcopenia (men with probable sarcopenia: 9.5±3.3 Kgf, women with probable, confirmed, and severe sarcopenia: 11.7±2.5, 12.2±3.0, 11.8±1.8 Kgf, respectively). The analysis showed an association between the type of medication and degree of sarcopenia; diuretics were significantly associated with probable sarcopenia, and angiotensin II receptor blockers (alone or in combination with diuretics) was associated with absence of sarcopenia. Conclusions: In conclusion, handgrip strength was a good method to diagnose sarcopenia, and diuretics were associated with increased risk of sarcopenia in older adults with hypertension.