Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease.
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Date
2010
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Abstract
Oxidative stress is common in inflammatory processes associated with many diseases including
Chagas’ disease. The aim of the present study was to evaluate, in a murine model, biomarkers of
oxidative stress together with components of the antioxidant system in order to provide an overview
of the mechanism of action of the iron chelator desferrioxamine (DFO). The study population
comprised 48 male Swiss mice, half of which were treated daily by intraperitoneal injection of DFO
over a 35-day period, while half were administered sterile water in a similar manner. On the 14th
day of the experiment, 12 DFO-treated mice and an equal number of untreated mice were
experimentally infected with Trypanosoma cruzi. Serum concentrations of nitric oxide and
superoxide dismutase and hepatic levels of total glutathione, thiobarbituric acid reactive species
and protein carbonyl, were determined on days 0, 7, 14 and 21 post-infection. The results obtained
revealed that DFO enhances antioxidant activity in the host but also increases oxidative stress,
indicating that the mode of action of the drug involves a positive contribution to the host together
with an effect that is not beneficial to the parasite.
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Keywords
Oxidative stress, Trypanosoma cruzi
Citation
FRANCISCO, A. F. et al. Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. Redox Report, v. 15, p.185-190, 2010. Disponível em: <http://www.tandfonline.com/action/showCopyRight?scroll=top&doi=10.1179/174329210X12650506623528>. Acesso em: 10 jan. 2017.