Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease.

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dc.contributor.authorFrancisco, Amanda Fortes
dc.contributor.authorVieira, Paula Melo de Abreu
dc.contributor.authorArantes, Jerusa Marilda
dc.contributor.authorSilva, Maísa
dc.contributor.authorPedrosa, Maria Lúcia
dc.contributor.authorSantos, Silvana Maria Elói
dc.contributor.authorMartins Filho, Olindo Assis
dc.contributor.authorCarvalho, Andréa Teixeira de
dc.contributor.authorAraújo, Márcio Sobreira Silva
dc.date.accessioned2017-02-23T17:19:41Z
dc.date.available2017-02-23T17:19:41Z
dc.date.issued2010
dc.description.abstractOxidative stress is common in inflammatory processes associated with many diseases including Chagas’ disease. The aim of the present study was to evaluate, in a murine model, biomarkers of oxidative stress together with components of the antioxidant system in order to provide an overview of the mechanism of action of the iron chelator desferrioxamine (DFO). The study population comprised 48 male Swiss mice, half of which were treated daily by intraperitoneal injection of DFO over a 35-day period, while half were administered sterile water in a similar manner. On the 14th day of the experiment, 12 DFO-treated mice and an equal number of untreated mice were experimentally infected with Trypanosoma cruzi. Serum concentrations of nitric oxide and superoxide dismutase and hepatic levels of total glutathione, thiobarbituric acid reactive species and protein carbonyl, were determined on days 0, 7, 14 and 21 post-infection. The results obtained revealed that DFO enhances antioxidant activity in the host but also increases oxidative stress, indicating that the mode of action of the drug involves a positive contribution to the host together with an effect that is not beneficial to the parasite.pt_BR
dc.identifier.citationFRANCISCO, A. F. et al. Increase of reactive oxygen species by desferrioxamine during experimental Chagas' disease. Redox Report, v. 15, p.185-190, 2010. Disponível em: <http://www.tandfonline.com/action/showCopyRight?scroll=top&doi=10.1179/174329210X12650506623528>. Acesso em: 10 jan. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1179/174329210X12650506623528
dc.identifier.issn1351-0002
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7311
dc.identifier.uri2http://www.tandfonline.com/action/showCopyRight?scroll=top&doi=10.1179/174329210X12650506623528pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectOxidative stresspt_BR
dc.subjectTrypanosoma cruzipt_BR
dc.titleIncrease of reactive oxygen species by desferrioxamine during experimental Chagas' disease.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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