Phytochemical characterization and antioxidant, antibacterial and antimutagenic activities of aqueous extract from leaves of Alchornea glandulosa.

Simple item page
dc.contributor.authorGontijo, Douglas da Costa
dc.contributor.authorDiaz, Marisa Alves Nogueira
dc.contributor.authorBrandão, Geraldo Célio
dc.contributor.authorGontijo, Pablo da Costa
dc.contributor.authorOliveira, Alaide Braga de
dc.contributor.authorFietto, Luciano Gomes
dc.contributor.authorLeite, João Paulo Viana
dc.date.accessioned2019-04-15T14:59:39Z
dc.date.available2019-04-15T14:59:39Z
dc.date.issued2018
dc.description.abstractPlant extracts exist as a complex matrix which serves as a source of numerous bioactive metabolites. The ultra performance liquid chromatography with diode-array detection-coupled electrospray ionization-mass spectrometry/mass spectrometry technique was used to characterize the aqueous extract from leaves of Alchornea glandulosa (EAG), a species popularly used to treat gastrointestinal problems as an antiulcer agent. Quantification of phenolic derivatives was determined using Folin–Ciocalteu and aluminum trichloride (AlCl3) methods. In addition, antioxidant (2,2-diphenyl-1-picrylhydrazyl [DPPH• ] radical scavenging, β-carotene–linoleic acid, and lipid peroxidation), antibacterial (agar well diffusion method and minimum inhibitory concentration), antimutagenic (Ames test), and antigenotoxic (plasmid cleavage) assays were also performed on this plant extract. The ellagitannin tris-galloyl-hexahydroxydiphenic acid-glucose was identified as the predominant compound along with tannins as majority metabolites. EAG showed high antioxidant activity accompanied by moderate antibacterial activity against Staphylococcus aureus. The highest antimutagenic activity was observed for TA97 strain without metabolic activation (S9) and with metabolic activation, TA100 and TA102 were completely inhibited. In addition, EAG exhibited potential signs of antigenotoxic action. The high antioxidant and antimutagenic activity observed for EAG suggests important therapeutic uses that still need to be verified in future studies.pt_BR
dc.identifier.citationGONTIJO, D. da C. et al. Phytochemical characterization and antioxidant, antibacterial and antimutagenic activities of aqueous extract from leaves of Alchornea glandulosa. Journal of Toxicology and Environmental Health, Part A Current Issues, v. 81, n. 6, p. 2-14, 2018. Disponível em: <https://www.tandfonline.com/doi/abs/10.1080/15287394.2018.1492479?journalCode=uteh20>. Acesso em: 25 fev. 2019.pt_BR
dc.identifier.issn10872620
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/11019
dc.identifier.uri2https://www.tandfonline.com/doi/full/10.1080/15287394.2018.1492479pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.subjectPhenolic compoundspt_BR
dc.subjectlchornea glandulosapt_BR
dc.subjectDNA damagept_BR
dc.subjectAntioxidant and Antibacterial Actionpt_BR
dc.titlePhytochemical characterization and antioxidant, antibacterial and antimutagenic activities of aqueous extract from leaves of Alchornea glandulosa.pt_BR
dc.typeArtigo publicado em periodicopt_BR
Files
Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
ARTIGO_PhytochemicalCharacterizationAntioxidant.pdf
Size:
1.88 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
924 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
DEFAR - Artigos publicados em periódicos