Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.

Nunes, Kenia Pedrosa; Cordeiro, Marta do Nascimento; Richardson, Michael; Borges, Marcia Helena; Diniz, Simone Odília Antunes Fernandes; Cardoso, Valbert Nascimento; Tostes, Rita de Cassia Aleixo; Garcia, Maria Elena de Lima Perez; Webb, Robert Clinton; Leite, Romulo

Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.

Date

2010

Authors

Nunes, Kenia Pedrosa

Cordeiro, Marta do Nascimento

Richardson, Michael

Borges, Marcia Helena

Diniz, Simone Odília Antunes Fernandes

Cardoso, Valbert Nascimento

Tostes, Rita de Cassia Aleixo

Garcia, Maria Elena de Lima Perez

Webb, Robert Clinton

Leite, Romulo

Abstract

Introduction—Priapism is one of several symptoms observed in accidental bites by the spider Phoneutria nigriventer. The venom of this spider is comprised of many toxins, and the majority has been shown to affect excitable ion channels, mainly sodium (Na+) channels. It has been demonstrated that PnTx2-6, a peptide extracted from the venom of P. nigriventer, causes erection in anesthetized rats and mice. Aim—We investigated the mechanism by which PnTx2-6 evokes relaxation in rat corpus cavernosum. Main Outcome Measures—PnTx2-6 toxin potentiates nitric oxide (NO)-dependent cavernosal relaxation.

Citation

NUNES, K. P. et al. Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue. The Journal of Sexual Medicine, v. 7, p. 3879-3888, 2010. Disponível em: <http://www.sciencedirect.com/science/article/pii/S1743609515327995>. Acesso em: 10 jan. 2017.