Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.

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dc.contributor.authorNunes, Kenia Pedrosa
dc.contributor.authorCordeiro, Marta do Nascimento
dc.contributor.authorRichardson, Michael
dc.contributor.authorBorges, Marcia Helena
dc.contributor.authorDiniz, Simone Odília Antunes Fernandes
dc.contributor.authorCardoso, Valbert Nascimento
dc.contributor.authorTostes, Rita de Cassia Aleixo
dc.contributor.authorGarcia, Maria Elena de Lima Perez
dc.contributor.authorWebb, Robert Clinton
dc.contributor.authorLeite, Romulo
dc.date.accessioned2017-03-24T16:51:21Z
dc.date.available2017-03-24T16:51:21Z
dc.date.issued2010
dc.description.abstractIntroduction—Priapism is one of several symptoms observed in accidental bites by the spider Phoneutria nigriventer. The venom of this spider is comprised of many toxins, and the majority has been shown to affect excitable ion channels, mainly sodium (Na+) channels. It has been demonstrated that PnTx2-6, a peptide extracted from the venom of P. nigriventer, causes erection in anesthetized rats and mice. Aim—We investigated the mechanism by which PnTx2-6 evokes relaxation in rat corpus cavernosum. Main Outcome Measures—PnTx2-6 toxin potentiates nitric oxide (NO)-dependent cavernosal relaxation.pt_BR
dc.identifier.citationNUNES, K. P. et al. Nitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue. The Journal of Sexual Medicine, v. 7, p. 3879-3888, 2010. Disponível em: <http://www.sciencedirect.com/science/article/pii/S1743609515327995>. Acesso em: 10 jan. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1111/j.1743-6109.2010.01978.x
dc.identifier.issn 1743-6095
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/7460
dc.identifier.uri2http://www.sciencedirect.com/science/article/pii/S1743609515327995pt_BR
dc.language.isoen_USpt_BR
dc.rightsrestritopt_BR
dc.titleNitric oxide-induced vasorelaxation in response to PnTx2-6 toxin from Phoneutria nigriventer spider in rat cavernosal tissue.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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