Flavonol triglycosides of leaves from Maytenus robusta with acetylcholinesterase inhibition.
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Date
2017
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Abstract
Although Maytenus robusta aqueous infusions of leaves are used in Brazilian traditional medicine for
stomach disease treatment, only a few chemical studies of this species are found in literature. The
phytochemical investigation of methanol extract from M. robusta leaves yielded the known compound
kaempferol (3) and two new
flavonol glycosides: kaempferol-3-O-b-D-glucopyranosyl-(1
!3)-a-Lrhamnopyranosyl-(
1
!
2)-b-D-glucopyranoside (1) and quercetin-3-O-b-D-glucopyranosyl-(1
!3)-a-Lrhamnopyranosyl-(
1
!
2)-b-D-glucopyranoside (2). The chemical structures of 1 and 2 were elucidated
by 1D/2D NMR, ESI–MS and ESI–MS2 spectral data. It is the
first time
flavonoids have been reported from
M. robusta. Flavonols 1 and 2 showed 66% and 80% acetylcholinesterase (AChE) inhibition, compared to
93% of the standard eserine, by the Ellman’s method. These substances are one of the few active
flavonols
linked to a trisaccharide chain in the literature presenting this activity, and contribute to the screening for
new types of natural AChE inhibitors.
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Celastraceae
Citation
SOUSA, G. F. et al. Flavonol triglycosides of leaves from Maytenus robusta with acetylcholinesterase inhibition. Phytochemistry Letters, v. 19, p. 34-38, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S1874390016302282>. Acesso em: 29 ago. 2017.