Flavonol triglycosides of leaves from Maytenus robusta with acetylcholinesterase inhibition.

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dc.contributor.authorSousa, Grasiely Faria de
dc.contributor.authorAguiar, Mariana Guerra de
dc.contributor.authorTakahashi, Jacqueline Aparecida
dc.contributor.authorAlves, Tânia Maria de Almeida
dc.contributor.authorKohlhoff, Markus
dc.contributor.authorVieira Filho, Sidney Augusto
dc.contributor.authorSilva, Grácia Divina de Fátima
dc.contributor.authorDuarte, Lucienir Pains
dc.date.accessioned2017-08-30T18:26:32Z
dc.date.available2017-08-30T18:26:32Z
dc.date.issued2017
dc.description.abstractAlthough Maytenus robusta aqueous infusions of leaves are used in Brazilian traditional medicine for stomach disease treatment, only a few chemical studies of this species are found in literature. The phytochemical investigation of methanol extract from M. robusta leaves yielded the known compound kaempferol (3) and two new flavonol glycosides: kaempferol-3-O-b-D-glucopyranosyl-(1 !3)-a-Lrhamnopyranosyl-( 1 ! 2)-b-D-glucopyranoside (1) and quercetin-3-O-b-D-glucopyranosyl-(1 !3)-a-Lrhamnopyranosyl-( 1 ! 2)-b-D-glucopyranoside (2). The chemical structures of 1 and 2 were elucidated by 1D/2D NMR, ESI–MS and ESI–MS2 spectral data. It is the first time flavonoids have been reported from M. robusta. Flavonols 1 and 2 showed 66% and 80% acetylcholinesterase (AChE) inhibition, compared to 93% of the standard eserine, by the Ellman’s method. These substances are one of the few active flavonols linked to a trisaccharide chain in the literature presenting this activity, and contribute to the screening for new types of natural AChE inhibitors.pt_BR
dc.identifier.citationSOUSA, G. F. et al. Flavonol triglycosides of leaves from Maytenus robusta with acetylcholinesterase inhibition. Phytochemistry Letters, v. 19, p. 34-38, 2017. Disponível em: <http://www.sciencedirect.com/science/article/pii/S1874390016302282>. Acesso em: 29 ago. 2017.pt_BR
dc.identifier.doihttps://doi.org/10.1016/j.phytol.2016.10.024
dc.identifier.issn1874-3900
dc.identifier.urihttp://www.repositorio.ufop.br/handle/123456789/8611
dc.language.isoen_USpt_BR
dc.rightsabertopt_BR
dc.rights.licenseO periódico Phytochemistry Letters concede permissão para depósito deste artigo no Repositório Institucional da UFOP. Número da licença: 4178720474114.
dc.subjectCelastraceaept_BR
dc.titleFlavonol triglycosides of leaves from Maytenus robusta with acetylcholinesterase inhibition.pt_BR
dc.typeArtigo publicado em periodicopt_BR
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