Biological activities of extracts from Padina Boergesenii and Sargassum Stenophyllum, seaweeds naturally found in Baia de Todos os Santos, Brazil.

Oliveira, Naiara Maia; Meira, Carla Larissa Costa; Aguiar, Rosane Moura; Oliveira, Djalma Menezes de; Moura, Carlos Wallace do Nascimento; Vieira Filho, Sidney Augusto

Biological activities of extracts from Padina Boergesenii and Sargassum Stenophyllum, seaweeds naturally found in Baia de Todos os Santos, Brazil.

Date

2015

Authors

Oliveira, Naiara Maia

Meira, Carla Larissa Costa

Aguiar, Rosane Moura

Oliveira, Djalma Menezes de

Moura, Carlos Wallace do Nascimento

Vieira Filho, Sidney Augusto

Abstract

Objective: Here we present the results of the biological potential as antioxidant, anti-cancer and leishmaniscidal from extracts of Padina boergesenii Allender & Kraft and of Sargassum stenophyllum Martius, seaweed species commonly found in bay of the Brazilian Atlantic coast named Baía de Todos os Santos, state Bahia. In addition, we reported on the chemical composition of extractive fractions from these algae. Methods: Phytochemicals prospecting methods such as thin layer chromatography (TLC) and spectrometry in the UV/Vis region were used to identify the chemical class of constituents from these algae extracts. Antioxidant potential of the fractions was evaluated using the α,α-diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging method. The cytotoxic potential of seaweed extracts against the human breast cancer (MFC-7) cell lines was evaluated using the sulforhodamine B (SRB) colorimetric assay. The leishmanicidal effect of algae extracts against promastigotes of Leishmania amazonenses Laison & Shaw 1972 was evaluated using amphotericin B (AMB) as positive control. Results: Were detected flavonoids, steroids, carotenoids, anthocyanins and phenolic compounds from algae extracts in hexane, chloroform and n-butanol. Overall, extractive fractions showed moderate antioxidant activities in comparison with quecertin, butylated hydroxytoluene and gallic acid. Fractions from P. boergesenii and chloroform fraction of S. stenophyllum presented significant activity against MCF-7 cells by inhibiting the cells grown among 55.0 to 66.0 %. These results were closely similar to inhibition reached by colchicine (67.0 %) used as positive control. No antileishmanial significant effect was observed for P. boergesenii and S. stenophyllum extracts at the tested conditions. Conclusion: The results indicated a promissory pharmacologic potential for the P. boergesenii and S. stenophyllum extracts, Which open perspectives to the isolation of their active constituents.

Keywords

Cell inhibition, Anti-Leishmania

Citation

OLIVEIRA, N. M. et al. Biological activities of extracts from Padina Boergesenii and Sargassum Stenophyllum, seaweeds naturally found in Baia de Todos os Santos, Brazil. International Journal of Pharmacy and Pharmaceutical Sciences, v. 7, p. 350-353, 2015. Disponível em: <https://innovareacademics.in/journals/index.php/ijpps/article/view/3540>. Acesso em: 16 jun. 2017.