Browsing by Author "Mancuzo, Eliane Viana"

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    Fatores comportamentais, ambientais, marcadores genéticos e a tuberculose : estudo caso controle na Microrregião dos Inconfidentes e Ponte Nova.
    (2016) Guerra, Rosane Maria Lima; Coelho, George Luiz Lins Machado; Queiroz, Erica Maria de; Coelho, George Luiz Lins Machado; Mancuzo, Eliane Viana; Gonçalves, Luana Giatti
    A tuberculose (TB) é a principal doença infecciosa no mundo. Pode ser influenciada por fatores genéticos, ambientais e co-morbidades (HIV e Diabetes Mellitus). As variações genéticas estão normalmente associadas à diversidade populacional, à individualidade, à susceptibilidade a doenças e resposta individual a medicamentos. O objetivo do estudo foi verificar a presença de associação entre marcadores genéticos e fatores de exposição com a ocorrência de TB pulmonar ativa. Estudo caso-controle pareado por sexo, idade e local de residência foi realizado com indivíduos da região dos Inconfidentes e Ponte Nova entre 2013 e 2015. As informações foram coletadas através de questionário, coleta de sangue e dos dados clínicos nos prontuários dos indivíduos. A distribuição de frequência das variáveis e tabelas de contingência da distribuição dos fatores de exposição e dos genótipos entre casos e controles foi realizada e as associações analisadas pelo teste do qui-quadrado. As análises univariada e regressão logística multivariada condicional foram realizadas para avaliar associação entre os polimorfismos de nucleotídeos únicos (SNPs) selecionados e o risco de TB estimando a Odds relativa (OR). Dos 61 casos, 18 foram prevalentes em 2013 e os demais incidentes a partir de 2014 com o início da pesquisa. 72,1% dos casos com TB ativa eram homens e 27,9% mulheres, com idade média de 46,5+-14,8 anos de idade. Entre os grupos, não foram observadas diferenças significativas para as variáveis cor da pele, estado civil, renda familiar, escolaridade, fumo, IMC e pessoas por quarto. Os fatores de exposição associados aos casos foram: alcoolismo (CAGE) (OR= 10,97, IC: 4,24-28,37 p<0,001), ser ex-usuário de drogas (OR= 5,0, IC: 1,56-17,04 p=0,007) e ter tido contato com paciente com TB (OR=6,53, IC:2,68-15,91 p<0,001). Não foram observadas diferenças significativas para as frequências alélicas e genotípicas dos polimorfismos estudados (SNPs rs2057178, rs4331426, rs1800896 e rs1800629). Concluímos que este estudo reaviva a importância de intensificar a busca ativa dos sintomáticos respiratórios e seus contatos, melhorando o diagnóstico e a assistência aos doentes.
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    Lung function of patients hospitalized with COVID-19 at 45 days after hospital discharge : first report of a prospective multicenter study in Brazil.
    (2021) Mancuzo, Eliane Viana; Marinho, Carolina Coimbra; Coelho, George Luiz Lins Machado; Batista, Aline Priscila; Andrade, Bruno Horta; Brandão, Álvaro Lucca Torres; Leite, Ana Sophia Mitre; Ferreira, Pedro Chaves; Roveda, José Reinaldo Corrêa; Leite, Arnaldo Santos; Augusto, Valéria Maria
    Objective: Because SARS-CoV-2 infection can severely affect the lungs and persistent functional changes can occur after severe disease, we aimed to determine lung function parameters of COVID-19 patients at 45 days after hospital discharge and compare changes according to the severity of the disease. Methods: This was a prospective descriptive analytical multicenter study. The participants were allocated into three groups: ward admission (WA) group; ICU admission not on mechanical ventilation (ICU/ MV−) group; and ICU admission on MV (ICU/MV+) group. Lung volumes, DLco, MIP, MEP, and six-minute walk distance (6MWD) were measured 45 days after discharge. Results: The sample comprised 242 patients (mean age = 59.4 ± 14.8 years; 52.1% of males), and 232 (96%) had altered lung function. In the total cohort, restrictive disorder was observed in 96%, as well as reductions in DLco (in 21.2% of the patients), FEV1 /FVC (in 39.7%), and PEmax (in 95.8%), with no differences between the groups. Comparing the groups, the ICU/MV+ group had reduced DLco in 50% of the patients (p < 0.001) and a lower mean 6MWD % of the predicted value (p = 0.013). Oxygen desaturation in the six-minute walk test was observed in 32.3% of the cohort and was less frequent in the IE group. Conclusions: This is the first South American study involving severe COVID-19 survivors whose lung function was assessed 45 days after hospital discharge. Changes were frequent, especially in those on MV, which highlights the importance of lung function evaluation after severe COVID-19.
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    Lung function six months after severe COVID-19 : does time, in fact, heal all wounds?
    (2022) Bretas, Daniel Cruz; Leite, Arnaldo Santos; Mancuzo, Eliane Viana; Prata, Tarciane Aline; Andrade, Bruno Horta; Oliveira, Jacqueline das Graças Ferreira; Batista, Aline Priscila; Coelho, George Luiz Lins Machado; Augusto, Valéria Maria; Marinho, Carolina Coimbra
    Background COVID-19 has been associated with persistent symptoms and functional changes, especially in those surviving severe disease. Methods We conducted a prospective multicenter study in patients with severe COVID-19 to determine respiratory sequelae. Patients were stratified into two groups: ward admission (WA) and intensive care unit (ICU) admission. In each follow-up visit, the patients where inquired about cough and dyspnea, and performed spirometry, lung volumes, carbon monoxide diffusion capacity (DLCO), 6-minute walk test (6MWT), and respiratory muscle strength (MIP and MEP). Results of pulmonary function tests at 45 days and 6 months after hospital admission were compared using paired analysis. Results 211 patients were included, 112 in WA and 99 in ICU. Dyspnea persisted in 64.7% in the WA and 66.7% in the ICU group after 6 months. Lung function measures showed significant improvement between 45 days and 6 months, both in WA and ICU groups in VC, FVC, FEV1, total lung capacity, and 6MW distance measures. The improvement in the proportions of the altered functional parameters was significant in the ICU group for VC (44.2% 45 d; 20.8% 6 m; p = 0,014), FVC (47.6% 45 d; 28% 6 m; p = 0,003), FEV1 (45.1% 45 d; 28% 6 m; p = 0,044), DLCO (33.8% 45 d; 7.7% 6 m; p < 0,0001). Conclusion Six months follow-up of patients with the severe forms of COVID-19 showed significant improvement in the lung function measures compared to 45 days post hospital discharge. The difference was more evident in those requiring ICU admission.
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    Pulmonary functional assessment : longitudinal study after treatment of pulmonary tuberculosis.
    (2021) Nishi, Marina Pires; Mancuzo, Eliane Viana; Sulmonett, Nara; Almeida, Isabela Neves de; César, Aina Liz Alves; Miranda, Silvana Spíndola de
    Even when treated adequately, pulmonary tuberculosis can lead to pulmonary sequelae. Patients treated for PTB between 2012 and 2016 answered a standardized questionnaire and underwent chest radiography and spirometry, measurement of absolute pulmonary volume, Diffusing Capacity for Carbon Monoxide (DLCO) and the 6-min walk test (6MWT) on two occasions: within the first year after the end of treatment (follow-up 1), and one and two years after follow-up 1 (follow-up 2). A total of 55 patients they underwent spirometry, 23 (41.82%) had obstructive ventilatory disorder (OVD) and eight (14.5%) had moderate OVD. In total, 29 patients underwent pulmonary function tests (PFTs) and 24 patients underwent the 6MWT on two occasions. The functional changes after PTB treatment appear not to have varied between one and two years of follow-up. There was a correlation between low FEV1 and low DLCO (p<0.001); low DLCO and low 6MWT (p<0.001) and radiographic abnormalities and low FEV1 (p=0.033). The most frequently observed change in spirometry was found in patients with OVD.